Peer-reviewed research and publications featuring NovaScan and our innovative cancer detection technology.
Medical Research Archives, Volume 13 Issue 5May 31, 2025
Bioelectrical Impedance Analysis for Breast Cancer: Diagnosis, Prognosis, and Tissue Mapping
Authors:
Donato M. Ceres, PhD, Wendy M. Mikkelson, MD, Christopher W. Gregory, PhD, James J. Marx, PhD, William D. Gregory, PhD
This comprehensive review summarizes more than two decades of work on the use of bioelectrical impedance in cancer research and clinical applications. The Cole relaxation frequency (CRF), derived from impedance spectroscopy, effectively differentiates malignant from benign breast tissue and serves as a strong prognostic marker. The review also presents Electrical Property Enhanced Tomography (EPET) as a significant advancement for in-vivo imaging of tissue electrical properties.
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2023
A "SMART ROSE" DEVICE FOR IMMEDIATE FEEDBACK ON SAMPLE ADEQUACY AND CANCER PRESENCE IN PANCREATIC BIOPSIES: INITIAL RESULTS FROM HUMAN CLINICAL TRIAL WITH NSCANARY
Authors:
Federica Dibennardo, Martina Guidetti, Alexander Grycuk, Onur Fidaner, Daniel Gehrke, Donato Ceres, Margaret John, Constantine Bovalis, Isaac Raijman, Les Bogdanowicz
This study presents initial results from a human clinical trial evaluating a "Smart ROSE" device (nsCanary) designed to provide immediate feedback on sample adequacy and cancer presence in pancreatic biopsies. The device demonstrates the potential to improve the accuracy and efficiency of pancreatic biopsy procedures.
2022
Cole Relaxation Frequency for the Detection of Pancreatic Cancer and Precancerous Conditions
Authors:
Les Bogdanowicz, PhD, MBA, Martina Guidetti, PhD, Onur Fidaner, PhD, Daniel Gehrke, BS, Alexander Grycuk, BS, Donato Ceres, PhD, Margaret John, BS, Constantine Bovalis, BS, Erik Kundro, PhD, Karla J. Castellanos, PhD, MS, Akshar Patel, BS, Adonis Coleman, UG, Lobna Elkhadragy, PhD, Brian T. Layden, MD, PhD, Cemal Yazici, MD, MSc, Isaac Raijman, MD, Paul J. Grippo, PhD
This research explores the application of Cole Relaxation Frequency as a diagnostic tool for detecting pancreatic cancer and precancerous conditions, offering a potential non-invasive method for early detection of this challenging disease.
2022
Cole Relaxation Frequency: A Parameter for Pancreatic Cancer Detection
Authors:
Les Bogdanowicz, PhD, Martina Guidetti, PhD, Onur Fidaner, PhD, Daniel S Gehrke, Alexander Grycuk, Donato Ceres, PhD, Margaret C John, Constantine H Bovalis, Erik M Kundro, Karla Castellanos, Akshar Patel, Isaac Raijman, MD, Paul Grippo, PhD
This pilot study investigates whether Cole Relaxation Frequency (CRF), an electrical bioimpedance signature developed by NovaScan, can detect cancer in pancreatic tissues. Pancreatic cancer is a highly lethal malignancy with limited current detection methods, and this research aims to extend CRF technology, which has shown promise in breast, skin, and lung cancer detection, to pancreatic cancer diagnosis.
2022
Cole Relaxation Frequency: A Parameter to Assess Lymph Node Status in Patients with Lung Cancer
Authors:
Martina Guidetti, Les Bogdanowicz, Onur Fidaner, Donato Ceres, Alexander Grycuk, Daniel S Gehrke, Margaret Hoeller, Constantine Bovalis, David Demos
Lung cancer is the world's leading cause of cancer deaths, and early, accurate diagnosis remains challenging. This pilot study investigates whether NoduleScan, a Cole Relaxation Frequency (CRF) based technology developed by NovaScan to detect cancer in the lungs, can be used for lymph node assessment. CRF has been proven to detect cancer in breast, skin, and lung tissues, and this research aims to extend its application to assess lymph node status in lung cancer patients.
JMIR BIOMEDICAL ENGINEERING2022
The Cole Relaxation Frequency as a Parameter to Identify Cancer in Lung Tissue: Preliminary Animal and Ex Vivo Patient Studies
Authors:
Les Bogdanowicz, PhD, Onur Fidaner, PhD, Donato Ceres, PhD, Alexander Grycuk, BS, Martina Guidetti, PhD, David Demos, MD
This study presents preliminary findings from animal and ex vivo patient studies investigating the use of Cole Relaxation Frequency (CRF) as a parameter to identify cancer in lung tissue. The research demonstrates the potential application of CRF-based technology for lung cancer detection.
Volume 7 issue 44 -- women and cancer2020
Cole Relaxation Frequency as a Prognostic Parameter for Breast Cancer
Authors:
William D. Gregory, Shahila Mehboob Christie, John Shell, Georges J. Nahhas, Maharaj Singh, Wendy Mikkelson
This research examines Cole Relaxation Frequency as a prognostic parameter for breast cancer, exploring its potential to predict patient outcomes and disease progression. The study contributes to the understanding of how CRF can be used for prognostic assessment in breast cancer management.
2020
Bioimpedance Based Biomarker for the Detection of Precancerous and Cancerous Lesions of the Pancreas: Feasibility Animal Study
Authors:
Federica Dibennardo, Martina Guidetti, Alexander Grycuk, Onur Fidaner, Daniel S Gehrke, Donato Ceres, Margaret C John, Constantine H Bovalis, Erik M Kundro, Karla Castellanos, Akshar Patel, Isaac Raijman, Paul Grippo, Les Bogdanowicz
This feasibility animal study investigates the use of bioimpedance-based biomarkers for detecting precancerous and cancerous lesions of the pancreas. The research evaluates the potential of this non-invasive method for early detection of pancreatic malignancies, addressing a critical need for improved diagnostic approaches.
JAMACADDERMATOL VOLUME79,NUMBER32018
Bioimpedance Measurement as an Assessment of Margin Positivity in Mohs Surgical Specimens of Nonmelanoma Skin Cancer: Management Implications
This study evaluates the use of bioimpedance measurement to assess margin positivity in Mohs surgical specimens of nonmelanoma skin cancer. The research explores how this technology can provide real-time feedback on surgical margins and discusses the management implications for skin cancer surgery.
Medical Physics, Vol. 39, No. 7, July 20122012
The Cole Relaxation Frequency as a Parameter to Identify Cancer in Breast Tissue
Authors:
W. D. Gregory, J. J. Marx, C. W. Gregory, W. M. Mikkelson, J. A. Tjoe, J. Shell
This foundational research establishes the use of Cole Relaxation Frequency as a parameter to identify cancer in breast tissue. The study demonstrates the diagnostic potential of CRF for distinguishing between malignant and benign breast tissue, contributing to the development of non-invasive cancer detection methods.